超声场中凹球面内受束微泡的动力学行为研究

doi:10.16182/j.issn1004731x.joss.201803014

摘要/Abstract

摘要： 超声场中利用超声造影剂微泡UCA(ultrasound contrast agent)与凹球面间的相互作用来了解微泡在血管壁附近的声响应。基于“虚像法”及壁面的声反射效应,建立了一个UCA微泡在凹球形面内的动力学模型,通过数值计算分析了受束微泡的动力学行为。结果表明：在壁面附近时微泡振动受到压制,且刚性壁面对微泡振动的抑制比柔性壁面强;凹球面半径越小,或凹球面中心角越大,微泡振动越易受到抑制;在完全封闭球面内,球面半径越大,对微泡振动影响越弱。该模型为理解超声微泡在血管内的动力学响应及其在超声影像和药物传递中的应用提供理论参考。

关键词: 超声造影剂微泡, 超声, 凹球面, 动力学响应

Abstract: The interactions between an ultrasound contrast agent (UCA) microbubble and a concave surface can be applied to understanding of the response of the UCA near blood vessel wall in ultrasound field. A dynamics model of microbubble near a concave wall is presented by a virtual image method and the acoustic reflection effects of the surface. The dynamic behavior of the microbubble is analyzed by numerical calculation. The results show that the microbubble vibration is suppressed near the wall. Inhibitory effects to microbubble vibration near rigid wall are stronger than that of near elastic wall. The microbubble vibration is easier to be suppressed with smaller concave radius or central angle of the concave wall. In the fully enclosed sphere, the larger the sphere radius is, the weaker the effect on the microbubble vibration becomes. This simulation model may provide reference for understanding the dynamics response of microbubble in vessel, and its application in ultrasound contrast imaging and drug delivery.

Key words: UCA microbubble, ultrasound, concave wall, dynamic response

中图分类号:

胡继文, 孙佳娜. 超声场中凹球面内受束微泡的动力学行为研究[J]. 系统仿真学报, 2018, 30(3): 880-885.

Hu Jiwen, Sun Jiana. Dynamics of Microbubble Confined in Concave Wall in Ultrasound Filed[J]. Journal of System Simulation, 2018, 30(3): 880-885.

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